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Oral doses of vitamin D were tested for the treatment of psoriasis. This was caused by experiments with cholecalciferol or 1,25 dihydroxyvitamin D3 (1.25 (OH) 2D3), of the active form of vitamin D in the kidney, the promise in the treatment of psoriasis showed widespread.
With a microgram dose of cholecalciferol, Japanese researchers in 1986, succeeded in 13 of 17 psoriatic patents within three months to treat. But there are riskswith this therapy.
High doses of vitamin D often leads to hypercalcaemia (high calcium levels in the blood), which is characterized by nausea, vomiting, drowsiness, confusion, hypertension, renal failure and coma. This was observed in the Japanese study and may, in the under 1000 lus (international units) or more vitamin D occur.
Topical application of cholecalciferol by the same researchers proved to be useful and less toxic. Sixteen ofof 19 patients were within three weeks with a dose of 0.5 micrograms per gram, compared to three months treatment with oral doses. Nevertheless, the possibility remained, hypercalcemia, since vitamin D is absorbed through the skin.
That was Leo Pharmaceutical Products sought to researchers in Denmark, a new form of vitamin D, which might clear up psoriatic plaques minus the risks that we develop both oral and current applications of cholecalciferol to. This ledthe discovery of calcipotriol.
Calcipotriol is a vitamin D3 derivative, which is as effective as cholecalciferol in controlling the rapid growth of cells in psoriatic skin still 100 - 200 times less likely to produce hypercalcemia on. Unlike other creams and ointments, it is colorless and odorless, and generally well tolerated by patients.
The vitamin D3 analogues for the treatment of plaque psoriasis recommended and can be used alone or in combination with UVBRadiation (formerly referred to in this series in attack). The exact mechanism is unknown, but calcipotriol, numerous studies have established the effectiveness of this drug.
Controlled clinical trials have shown that calcipotriol is only as effective as some steroids and more effective than anthranol (both of which were discussed in this series) in the treatment of plaque psoriasis. Patients with the recommended dose of 50 micrograms per gram twice daily for six months have not evolvedHypercalcemia that calcipotriol safer than other conven ¬ len psoriasis therapies.
The long-term effects of calcipotriol, however, are unknown, and the safety of children and pregnant women has not been studied. With more of the substance can be dangerous. If you go over the recommended dose, and more than 100 grams per week, you can suffer from high blood calcium levels.
So far the only reported side effect is a mild skin irritation that occurs in 10 to 20 percent of thePatients who used calcipotriol. However, this can be controlled by careful application. Calcipotriol should not be on the face and the patients are advised to wash away traces of the ointment used inadvertently affect other areas, contact the skin. If you experience skin irritation, stop treatment and seek immediate medical attention.
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Sources of vitamin K
Almost everyone has been watching "Popeye" on television and has been in awe, as he immediately gained strength when he ate his spinach. We all just assumed that the spinach, which he was strong. Very few people take the time to wonder what it found in spinach to make it so powerful. Something that looked like a magic actually too many children vitamin K, which is the most important vitamins in spinach. Other green leafy vegetables which are high in vitaminK are lettuce, cabbage, kale and broccoli. A rule of thumb is, the greener the vegetable, the higher the vitamin K content.
Other sources of vitamin K in your diet is olive oil, soybean oil and cottonseed oil. Parsley is very rich in vitamin K. In fact, if you are 2 tablespoons of parsley, you 153% of the recommended daily amount of vitamin K. Preserving the largest dietary form of vitamin K vitamin K1) (phylloquinone. Good sourcesof vitamin K1 are chicken egg yolk, cow liver, butter and most cheeses.
Vitamin K for blood clotting
Many of the vitamins we take in our diet for all of us understand how vitamin C or vitamin D. All of us, vitamin C comes from oranges, fruit and vitamin D is made from milk with other foods. However, we are not all so familiar with some other vitamins, as we should, such as vitamin K. In fact, untilIt is our attention is called, many of us are not aware of the many benefits of vitamin K. The most important benefit of vitamin K is its ability to help our blood clot. For example, if you are cut, if your blood would not clot, you continue to bleed. Without this important vitamin in our system, bleeding could spiral out of control and a serious life-threatening condition. Therefore, you will see the seriousness of the proper amounts of vitamin K inour bodies, whether from the vitamin-rich food that we eat or vitamins.
Vitamin K for Seniors
Help for our most important function of blood clotting can vitamin K, but it is not the only important function for this vital vitamin. Vitamin K is intended to help the bone density of elderly people. (Popeye was definitely strong bones!) This is very beneficial for the elderly to help to prevent osteoporosis, adegenerative disease characterized by weakened bones. Even if some do not believe that's been scientifically proven, with all its other good points, it can not hurt to take this important vitamin K at regular intervals.
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