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Oral doses of vitamin D were tested for the treatment of psoriasis. This was caused by experiments with cholecalciferol or 1,25 dihydroxyvitamin D3 (1.25 (OH) 2D3), of the active form of vitamin D in the kidney, the promise in the treatment of psoriasis showed widespread.
With a microgram dose of cholecalciferol, Japanese researchers in 1986, succeeded in 13 of 17 psoriatic patents within three months to treat. But there are riskswith this therapy.
High doses of vitamin D often leads to hypercalcaemia (high calcium levels in the blood), which is characterized by nausea, vomiting, drowsiness, confusion, hypertension, renal failure and coma. This was observed in the Japanese study and may, in the under 1000 lus (international units) or more vitamin D occur.
Topical application of cholecalciferol by the same researchers proved to be useful and less toxic. Sixteen ofof 19 patients were within three weeks with a dose of 0.5 micrograms per gram, compared to three months treatment with oral doses. Nevertheless, the possibility remained, hypercalcemia, since vitamin D is absorbed through the skin.
That was Leo Pharmaceutical Products sought to researchers in Denmark, a new form of vitamin D, which might clear up psoriatic plaques minus the risks that we develop both oral and current applications of cholecalciferol to. This ledthe discovery of calcipotriol.
Calcipotriol is a vitamin D3 derivative, which is as effective as cholecalciferol in controlling the rapid growth of cells in psoriatic skin still 100 - 200 times less likely to produce hypercalcemia on. Unlike other creams and ointments, it is colorless and odorless, and generally well tolerated by patients.
The vitamin D3 analogues for the treatment of plaque psoriasis recommended and can be used alone or in combination with UVBRadiation (formerly referred to in this series in attack). The exact mechanism is unknown, but calcipotriol, numerous studies have established the effectiveness of this drug.
Controlled clinical trials have shown that calcipotriol is only as effective as some steroids and more effective than anthranol (both of which were discussed in this series) in the treatment of plaque psoriasis. Patients with the recommended dose of 50 micrograms per gram twice daily for six months have not evolvedHypercalcemia that calcipotriol safer than other conven ¬ len psoriasis therapies.
The long-term effects of calcipotriol, however, are unknown, and the safety of children and pregnant women has not been studied. With more of the substance can be dangerous. If you go over the recommended dose, and more than 100 grams per week, you can suffer from high blood calcium levels.
So far the only reported side effect is a mild skin irritation that occurs in 10 to 20 percent of thePatients who used calcipotriol. However, this can be controlled by careful application. Calcipotriol should not be on the face and the patients are advised to wash away traces of the ointment used inadvertently affect other areas, contact the skin. If you experience skin irritation, stop treatment and seek immediate medical attention.
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